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KMID : 1123920040180010260
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 1 p.260 ~ p.264
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Pharmacological Effects of Bioactive Fractions from Brachyglottis monroi
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Kwag Jung-Sook
Kim Hyung-Min
Baek Seung-Hwa
Na Young-Soon
Perry Nigel B.
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Abstract
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The effects of bioactive fractions from Brachyglottis monroi on biological activity were investigated. this bioactive subfraction 6-5 is the most cytotoxic to P388 murine leukaemia cell lines. A comparison of IC/sub 50/ values of these subfraction in cancer cell lines showed that their susceptibility to these subfractions decreased in the following order; Fr. 6-5 > Fr. 6-3 > Fr. 6-6 > Fr. 6-1 > Fr. 6-2 > Fr. 6-4 by the MTT method. Silica gel flash column chromatography concentrated the cytotoxic activity in subfraction 6-5 which eluted with 30% and 40% ethyl acetate : hexane gave a major bioactive (51 mg, P388 IC/sub 50/ 8,286 ng/mL at 7.5 ㎍/disc).
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KEYWORD
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Brachyglottis monroi, P388 murine leukaemia cell lines, Cytotoxic activity
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